The Preclinical Safety, Toxicity and Pharmacokinetics (Pk) of Targeted Episcleral Delivery of Topotecan, Melphalan and Its Combination with Dexamethasone.
In this study, conducted under Good Laboratory Practices to support Investigational New Drug Application (IND) scientists at 3T characterized the safety and Pk of topotecan, melphalan and combinations with dexamethasone in support of its clinical development.for the treatment of retinoblastoma and uveal melanoma.
Both INDs are open at the Food and Drug Administration