3T's unique platform can be implanted under the conjunctiva in a minimally invasive—non-ocular penetrating—procedure



A review of ocular drug delivery modalities



The episcleral implant (D, in the figure below) is intended for periocular use by placement under the conjunctiva in contact with the episclera—the outer side of the sclera. It neither penetrates the sclera or the eye.







A 44-fold increase in the bioavailability of molecules to the retina could be achieved by the episcleral selective delivery in comparison to periocular injections.





In this proof of concept study while preserving all the dynamic ocular barriers, it was demonstrated that a significant (44-fold) improvement in the drug delivery to the retina could be achieved by the use of the selective episcleral drug delivery system.